Research: ABRAHAM,

Listed in Issue 118

Abstract

ABRAHAM, Department of Biochemistry, Christian Medical College, Bagayam, Vellore 632002, Tamil Nadu, India, premilaabraham@yahoo.com, reports that vitamin C may be beneficial in the prevention of paracetamol-induced kidney damage.

Background

There is no specific treatment for paracetamol-induced kidney damage. Vitamin C is an outstanding chain-breaking antioxidant and a free radical scavenger. The aim of the present study was to determine whether large doses of vitamin C are useful in the treatment of paracetamol-induced renal damage.

Methodology

This animal study was performed in rats.

Results

The administration of vitamin C to the paracetamol-treated rats prevented kidney damage either completely or partially. Lower doses of vitamin C were beneficial in the prevention of paracetamol-induced kidney injury when administered early and higher doses were beneficial when administered later.

Conclusion

Moderate doses of vitamin C may be useful in the prevention, and megadoses of vitamin C in the treatment of paracetamol-induced kidney damage. The mechanism of protection by vitamin C appears to be the regeneration of nonprotein thiols.

References

Abraham P. Vitamin C may be beneficial in the prevention of paracetamol-induced renal damage. Clinical & Experimental Nephrology 9 (1): 24-30, Mar 2005.

Comment

Comment: The above study demonstrating that administration of vitamin C may prevent paracetamol-induced kidney damage may actually save lives if implemented into the emergency procedures following paracetamol poisoning.

Munro Hall Clinic 2019

IJCA 2018 New Skyscraper

Scientific and Medical Network 2021

Cycle India 2020

Walk on the Wide Side Trek Kenya 2020

Big Heart Bike Ride South Africa 2020

top of the page