Listed in Issue 203


ZHANG and COLLEAGUES, Lady Davis Institute for Medical Research, McGill University, and Jewish General Hospital, 3755 Cote Sainte Catherine, Montreal, QC H3T 1E2, Canada. conducted a double-blind clinical of  vitamin C and D provision to assess whether these could improve the mood state of acutely hospitalized patients.


Hypovitaminosis C and D are highly prevalent in acutely hospitalized patients, but the clinical significance of these biochemical abnormalities is not known. Because deficiencies of vitamin C and D have been linked to psychological abnormalities, vitamin C or D provision could improve the mood state of acutely hospitalized patients.


Double-blind clinical trial of the effect of vitamin C (500 mg twice daily) or vitamin D (1000 IU twice daily) on mood, as assessed with a validated instrument, the Profile of Mood States.


Vitamin C therapy increased plasma (P < 0.0001) and mononuclear leukocyte (P = 0.014) vitamin C concentrations and was associated with a 34% reduction in mood disturbance (P = 0.013). Vitamin D therapy increased plasma 25-hydroxyvitamin D concentrations (P = 0.0004), but had no significant effect on mood.


Treatment of hypovitaminosis C improves the mood state of acutely hospitalized patients.


Zhang M, Robitaille L, Eintracht S and Hoffer LJ. Vitamin C provision improves mood in acutely hospitalized patients. Source Nutrition. 27(5): 530-3. May 2011.

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