Research: ZHANG and COLLEAGUES,

Listed in Issue 203

Abstract

ZHANG and COLLEAGUES, Lady Davis Institute for Medical Research, McGill University, and Jewish General Hospital, 3755 Cote Sainte Catherine, Montreal, QC H3T 1E2, Canada. l.hoffer@mcgill.ca conducted a double-blind clinical of  vitamin C and D provision to assess whether these could improve the mood state of acutely hospitalized patients.

Background

Hypovitaminosis C and D are highly prevalent in acutely hospitalized patients, but the clinical significance of these biochemical abnormalities is not known. Because deficiencies of vitamin C and D have been linked to psychological abnormalities, vitamin C or D provision could improve the mood state of acutely hospitalized patients.

Methodology

Double-blind clinical trial of the effect of vitamin C (500 mg twice daily) or vitamin D (1000 IU twice daily) on mood, as assessed with a validated instrument, the Profile of Mood States.

Results

Vitamin C therapy increased plasma (P < 0.0001) and mononuclear leukocyte (P = 0.014) vitamin C concentrations and was associated with a 34% reduction in mood disturbance (P = 0.013). Vitamin D therapy increased plasma 25-hydroxyvitamin D concentrations (P = 0.0004), but had no significant effect on mood.

Conclusion

Treatment of hypovitaminosis C improves the mood state of acutely hospitalized patients.

References

Zhang M, Robitaille L, Eintracht S and Hoffer LJ. Vitamin C provision improves mood in acutely hospitalized patients. Source Nutrition. 27(5): 530-3. May 2011.

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