Research: ZHANG and COLLEAGUES,

Listed in Issue 245

Abstract

ZHANG and COLLEAGUES, (1)Key Laboratory of Food Nutrition and Safety, Ministry of Education, Tianjin University of Science & Technology, Tianjin 300457, China zhangzesheng@tust.edu.cn investigated the effect of lutein on the lifespan of Drosophila melanogaster.

Background

Lutein is one of the major carotenoids in most fruits and vegetables.

Methodology

The effect of lutein on the lifespan of Drosophila melanogaster was investigated.

Results

Results revealed that 0.1mg lutein/ml diet could prolong their mean lifespan from 49.0 to 54.6 days. This was consistent with a significant reduction in malonyldialdehyde (MDA) level and increase in antioxidant enzyme activities of the flies fed with lutein-treated diet compared with those fed with basal diet. Paraquat (PQ) and H2O2 treatment tests demonstrated that lutein could prolong the survival time of the flies. Real-time polymerase chain reaction (RT-PCR) analysis indicated the gene expression of superoxide dismutase (SOD; SOD1 and SOD2), and catalase (CAT) in the lutein-treated group was up-regulated relative to that of the control group.

Conclusion

It was concluded that the lifespan-prolonging activity of lutein was partially by up-regulation of endogenous antioxidant enzymes.

References

Zhang Z(1), Han S, Wang H, Wang T. Lutein extends the lifespan of Drosophila melanogaster. Arch Gerontol Geriatr. 58(1):153-9. Jan-Feb 2014. doi: 10.1016/j.archger.2013.07.007. Epub Aug 8 2013.

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