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Research: ÖZGÜL and COLLEAGUES,
Listed in Issue 282
Abstract
ÖZGÜL and COLLEAGUES, 1 Department of General Surgery, Haseki Training and Research Hospital, İstanbul-Turkey. tatarcihad@gmail.com conducted a study in rats to establish the effects of alpha-tocopherol on acute pancreatitis and to try out an alpha-tocopherol treatment protocol .
Background
Acute pancreatitis is a disease with high morbidity and mortality, despite all the advances in technology. The overall mortality rate of acute pancreatitis is 10%, whereas the mortality rate in infected necrotizing pancreatitis is approximately 35%. In this study, we aimed to establish acute pancreatitis in rats in order to try out the alpha-tocopherol treatment protocol and to reveal the results biochemically and histopathologically.
Methodology
Twenty-four male Sprague-Dawley rats weighing between 300 and 350 g were used in the study. In Group 1, 80 µg/kg of normal saline was subcutaneously injected into eight rats; in Group 2, 80 µg/kg of cerulein was subcutaneously injected into eight rats; and in Group 3, 80 µg/kg of cerulein was subcutaneously injected into eight rats. In addition, 30 mg/kg of alpha-tocopherol was intraperitoneally injected into eight rats.
Results
The mean Schoenberg score, serum amylase, and lipase and Neutrophil Gelatinase-Associated Lipocalin (NGAL) levels were statistically significantly higher in Group 2 than in Group 1. The mean Schoenberg score and serum amylase and lipase levels were statistically significantly lower in Group 3 than in Group 2.
Conclusion
In this experimental study rat model of cerulein-induced acute pancreatitis, 30 mg/kg of alpha-tocopherol was injected intraperitoneally to examine its effect on pancreatitis. The improvement was observed in the histopathological examination of pancreatic tissues. We think that alpha-tocopherol may have a therapeutic effect on pancreatic tissue.
References
Halit Özgül, Cihad Tatar 1 , Bahri Özer, Hüsnü Aydın, Soner Sarı, Songül Peltek Özer. Effects of alpha-tocopherol on acute pancreatitis in rat. Ulus Travma Acil Cerrahi Derg; 25(1):1-6. doi: 10.5505/tjtes.2018.30413. Jan 2019.
