Research: WEBER and COLLEAGUES,

Listed in Issue 256

Abstract

WEBER and COLLEAGUES,  1. Department of Molecular Toxicology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), 14558 Nuthetal, Germany; 2. NutriAct-Competence Cluster Nutrition Research Berlin-Potsdam, 14458 Nuthetal, Germany; 3. Institute of Biological Chemistry and Nutrition, University of Hohenheim, 70599 Stuttgart, Germany; 4. URBC-NARILIS, University of Namur, 5000 Namur, Belgium; 5. National Institute of Public Health and the Environment (RIVM), 3720 BA Bilthoven, Netherlands; 6. Institute of Biological Research and Biotechnology, National Hellenic Research Foundation (NHRF), 11635 Athens, Greece; 7. Department of Experimental Pathology, University of Bologna, 40126 Bologna, Italy; 8. Nencki Institute of Experimental Biology, Polish Academy of Sciences, 02-093 Warsaw, Poland; 9. School of Medicine, University of Tampere, 33014 Tampere, Finland; 10. Department of Applied Nutritional Science/Dietetics, Institute of Nutritional Medicine, University of Hohenheim, 70599 Stuttgart, Germany; 11. Molecular Toxicology, Department of Biology, University of Konstanz, 78457 Konstanz, Germany;

12. German Center for Diabetes Research (DZD), 85764 Munich-Neuherberg, Germany;

13. German Center for Cardiovascular Research (DZHK), 13357 Berlin, Germany present data on protein carbonyls and plasma antioxidants and their relation with age in the European multicenter study MARK-AGE.

Background

Oxidative stress and antioxidants play a role in age-related diseases and in the aging process. We here present data on protein carbonyls, 3-nitrotyrosine, malondialdehyde, and cellular and plasma antioxidants (glutathione, cysteine, ascorbic acid, uric acid, α-tocopherol, and lycopene) and their relation with age in the European multicenter study MARK-AGE.

Methodology

To avoid confounding, only data from countries which recruited subjects from all three study groups (five of eight centres) and only participants aged ≥55 years were selected resulting in data from 1559 participants. These included subjects from (1) the general population, (2) members from long-living families, and (3) their spouses. In addition, 683 middle-aged reference participants (35-54 years) served as a control.

Results

After adjustment for age, BMI, smoking status, gender, and country, there were differences in protein carbonyls, malondialdehyde, 3-nitrotyrosine, α-tocopherol, cysteine, and glutathione between the 3 study groups. Protein carbonyls and 3-nitrotyrosine as well as cysteine, uric acid, and lycopene were identified as independent biomarkers with the highest correlation with age. Interestingly, from all antioxidants measured, only lycopene was lower in all aged groups and from the oxidative stress biomarkers, only 3-nitrotyrosine was increased in the descendants from long-living families compared to the middle-aged control group.

Conclusion

The authors conclude that both lifestyle and genetics may be important contributors to redox biomarkers in an ageing population. PMCID: PMC5539926 Free PMC Article

References

Weber D1,2, Stuetz W3, Toussaint O4, Debacq-Chainiaux F4, Dollé MET5, Jansen E5, Gonos ES6, Franceschi C7, Sikora E8, Hervonen A9, Breusing N3,10, Sindlinger T11, Moreno-Villanueva M11, Bürkle A11, Grune T1,2,12,13. Associations between Specific Redox Biomarkers and Age in a Large European Cohort: The MARK-AGE Project. Oxid Med Cell Longev. 2017:1401452. doi: 10.1155/2017/1401452. Epub 2017 Jul 19. 2017.

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