Research: WANG and COLLEAGUES,

Listed in Issue 242

Abstract

WANG and COLLEAGUES, (1)Department of Cardiology, Second Affiliated Hospital, Xi'an Jiaotong University,  157 Road Xiwu, Xi'an, Shaanxi, 710004, People's Republic of China studied the association between selenium (Se) deficiency-induced cardiac malfunction and endoplasmic reticulum (ER) stress in rats.

Background

The relationship between selenium (Se) deficiency-induced cardiac malfunction and endoplasmic reticulum (ER) stress is poorly understood.

Methodology

In the present study, 18 weaning Sprague Dawley rats were randomly fed with three different Se diets, and myocardial glutathione peroxidase (GPx) activity was measured by an enzyme activity assay. Cardiac function was evaluated by hemodynamic parameters. ER stress markers immunoglobulin-binding protein (BiP)/glucose-regulated protein 78 (GRP78) and C/EBP homologous protein (CHOP) were detected by western blotting.

Results

The authors’ data showed that myocardial GPx activity and cardiac function were conspicuously impaired in Se-deficient rats. Expression of GRP78 and CHOP was significantly upregulated by treatment of Se deficiency. Improvements in myocardial GPx activity and cardiac function, as well as decreases in expression of GRP78 and CHOP, were observed after Se supplementation.

Conclusion

Consequently, our data show that ER stress was involved in Se deficiency-induced cardiac dysfunction.

References

Wang SQ(1), Niu XL, Liu ZW, Zhu YH, Gao DF. Selenium deficiency is associated with endoplasmic reticulum stress in a rat model of cardiac malfunction. Biol Trace Elem Res. 156(1-3):196-201. Dec 2013. doi: 10.1007/s12011-013-9834-1. Epub Oct 1 2013.  

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