Research: VATASSERY and colleagues

Listed in Issue 36


VATASSERY and colleagues, GRECC, VA Medical Center, Department of Psychiatry, University of Minnesota, Minneapolis 55417 USA studied the association of alpha-tocopherol (vitamin E) concentrations and Parkinson's disease.



The concentration of alpha-tocopherol was determined in the cerebral spinal fluid (CSF) in patients with early untreated Parkinson's disease. Patients received 2,000 IU vitamin E orally each day.


Following treatment, concentrations increased significantly by 76+%. Net increases in CSF alpha-tocopherol concentrations following treatment showed a significant positive correlation with the number of days of vitamin E intake.


High-dose vitamin E treatment results in an elevation of vitamin E CSF levels and possibly brain vitamin E levels.


Vatassery GT et al. Alpha tocopherol in CSF of subjects taking high-dose vitamin E in the DATATOP study. Parkinson Study Group. Neurology 50(6): 1900-2. June 1998.

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