Research: TASCHEREAU-CHARRON and COLLEAGUES,

Listed in Issue 256

Abstract

TASCHEREAU-CHARRON and COLLEAGUES, 1. Endocrinology and Nephrology Unit, Centre de recherche du CHU de Québec-Université Laval, Quebec, QC, Canada; 2. Endocrinology and Nephrology Unit, Centre de recherche du CHU de Québec-Université Laval, Quebec, QC, Canada. Electronic address: iwona.rudkowska@crchudequebec.ulaval.ca reviewed the scientific literature to compare Fatty acid (FA)  profiles in different blood lipid fractions and the influence of dietary fat intake in women with gestational diabetes mellitus (GDM) or normoglycemic pregnancies.

Background

Gestational diabetes mellitus (GDM) is a pregnancy-induced complication with increased prevalence, especially in overweight women. Fatty acid (FA) composition in tissues can reflect dietary fat intake, especially essential FA intake.

Methodology

Moreover, it has been shown that FA profiles in blood lipid fractions are altered in diabetic patients. Consequently, women with GDM may also have a distinctive FA profile. The objective of this review is compare FA profiles in different blood lipid fractions and the influence of dietary fat intake in women with GDM or normoglycemic pregnancies.

Results

Results show that women with GDM have more saturated and less polyunsaturated FA (PUFA) in their red blood cell (RBC) membranes than normoglycemic pregnant women. Moreover, some studies reported that women with GDM have a greater energy intake from total fat and saturated FA, along with a lower energy intake from PUFA, when compared to normoglycemic pregnancies. Clinical trials showed that omega-3 PUFA levels in RBC membranes of GDM women can be restored by a dietary intervention.

Conclusion

Further research is required to determine whether FA profiles are altered prior to the diagnosis of GDM and can be prevented by diet.

References

Taschereau-Charron A1, Da Silva MS1, Bilodeau JF1, Morisset AS1, Julien P1, Rudkowska I2. Alterations of fatty acid profiles in gestational diabetes and influence of the diet. Maturitas. 99:98-104. doi: 10.1016/j.maturitas.2017.01.014. Epub 2017 Jan 27. May 2017.

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