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Research: SOLBERG and COLLEAGUES,
Listed in Issue 276
Abstract
SOLBERG and COLLEAGUES, Department of Pediatric Research, University of Oslo, Oslo University Hospital Rikshospitalet, Oslo, Norway set out to test the hypothesis that DHA provides significant protection against lipoperoxidation damage in the cerebral cortex and hippocampus using a neonatal piglet model of severe hypoxia-reoxygenation.
Background
Perinatal hypoxic-ischemic brain damage is a major cause of acute mortality and chronic neurological morbidity in infants and children. Oxidative stress due to free radical formation and the initiation of abnormal oxidative reactions appears to play a key role. Docosahexaenoic acid (DHA), a main component of brain membrane phospholipids, may act as a neuroprotectant after hypoxia-ischemia by regulating multiple molecular pathways and gene expression. The aims of this study were to test the hypothesis that DHA provides significant protection against lipoperoxidation damage in the cerebral cortex and hippocampus in a neonatal piglet model of severe hypoxia-reoxygenation.
Methodology
Newborn piglets, Noroc (LYLD), were subjected to severe global hypoxia. One group was resuscitated with ambient air (21% group, n = 11) and another also received 5 mg/kg of DHA 4 h after the end of hypoxia (21% DHA group, n = 10). After 9.5 h, tissues from the prefrontal cortex and hippocampus were sampled and the levels of isoprostanes, neuroprostanes, neurofurans, and F2-dihomo-isoprostanes were determined by the liquid chromatography triple quadrupole mass spectrometry technique.
Results
Lipid peroxidation biomarkers were significantly lower in both the cortex and hippocampus in the DHA-treated group compared with the untreated group.
Conclusion
The present study demonstrates that DHA administration after severe hypoxia in newborn piglets has an antioxidative effect in the brain, suggesting a protective potential of DHA if given after injuries to the brain.
References
Solberg R1, Longini M, Proietti F, Perrone S, Felici C, Porta A, Saugstad OD, Buonocore G. DHA Reduces Oxidative Stress after Perinatal Asphyxia: A Study in Newborn Piglets. Neonatology. 112(1):1-8. doi: 10.1159/000454982. Epub Feb 1 2017 . 2017.
