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Research: SAURAT, Department of
Listed in Issue 75
Abstract
SAURAT, Department of Dermatology, University Hospital and DHURDV, Geneva CH, Switzerland, analysed the effects of UV on epidermal stores of vitamin A and substances involved in its activity, storage, activation and protection.
Background
Significant amounts of vitamin A are stored in the human epidermis, along with enzymes involved in its storage or activation, protective binding proteins, transport molecules, and nuclear receptors involved in vitamin A-induced gene activity modulation. Vitamin A absorbs in the UV B range, so the vitamin A system may undergo marked alterations on exposure to UV light .
Methodology
The investigators carried out studies to examine the effects of UV on epidermal stores of vitamin A (retinol and retinyl esters), its enzymes and binding proteins, and some relevant biological parameters (e.g. expression of apoptosis transcription factors (cJun) and thymine dimers).
Results
Conclusion
References
Saurat JH. Skin, sun, and vitamin A: from aging to cancer. The Journal of Dermatology 28 (11): 595-8. Nov 2001.
