Research: RUGGIERO and COLLEAGUES,

Listed in Issue 181

Abstract

RUGGIERO and COLLEAGUES,  Institute of Gerontology and Geriatrics, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy. ruggieroc07@hotmail.it investigated the relationship between uric acid (UA) levels and dementia in older persons.

Background

The biological action of uric acid (UA) in humans is controversial. UA is considered an antioxidant compound, but preclinical evidence suggests a proinflammatory action. Epidemiological studies found that hyperuricemia is associated with conditions leading to dementia. Our aim is to investigate the relationship between UA levels and dementia in older persons.

Methodology

Cross-sectional study performed in 1,016 community-dwelling older persons participating in the InCHIANTI study. Participants underwent determination of circulating UA levels and neuropsychological evaluation. A multivariate logistic regression model was used to estimate the probability of participants belonging to the highest and middle UA tertile to be affected by dementia compared to those in the lowest tertile.

Results

Demented persons had higher UA levels (p = 0.001) and the prevalence of persons affected by dementia increased across UA tertiles (p < 0.0001). Independent of several confounders, persons belonging to the highest UA tertile had a threefold (OR = 3.32; 95% CI: 1.06-10.42) higher probability to suffer from a dementia syndrome while those in the middle UA tertile tended to have a higher probability of being demented compared to those in the lowest tertile.

Conclusion

In a population-based sample, high circulating UA levels are associated with an increased likelihood to be affected by a dementia syndrome.

References

Ruggiero C, Cherubini A, Lauretani F, Bandinelli S, Maggio M, Di Iorio A, Zuliani G, Dragonas C, Senin U and Ferrucci L. Uric acid and dementia in community-dwelling older persons. Dementia & Geriatric Cognitive Disorders. 27(4): 382-9. 2009.

Comment

The above research demonstrates the level of molecular research being applied to ageing research.

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