Positive Health Online

Abstract

QI and COLLEAGUES, (1)Gansu University of Chinese Medicine, Lanzhou, Gansu, China; (2)Gansu Provincial Cancer Hospital, Lanzhou, Gansu, China’ (3)Gansu University of Chinese Medicine, Lanzhou, Gansu, China lanzhoujinhua@126.com . set out to compare the treatment effects of different vitamins on essential hypertension to provide an initial basis for developing evidence-based practices

Background

Methodology

The objective of the current study is to compare the treatment effects of different vitamins on essential hypertension to provide an initial basis for developing evidence-based practices. Design: Systematic review and network meta-analysis. Data Sources: Five electronic databases (PubMed, Embase, Web of Science, Cochrane Central Register of Controlled Trials and ClinicalTrials.gov) were searched from their inception to 25 September 2023. Outcomes: The primary outcomes were the difference between the intervention group and the control group in changes in office systolic blood pressure (SBP) and office diastolic blood pressure (DBP) from baseline. The secondary outcomes were the difference between the intervention group and the control group in changes in 24-hour mean ambulatory systolic blood pressure (24 hours SBP), 24-hour mean ambulatory diastolic blood pressure (24 ho

Results

A total of 23 studies comparing five vitamins (vitamin B2, vitamin C, vitamin D, vitamin E, folic acid) and involving 2218 participants were included. The included trials were all vitamin versus placebo, so the network was star-shaped. Among the five vitamins, only vitamin E was significantly more effective at reducing SBP (mean difference: -14.14 mm Hg, 95% credible intervals: -27.62 to -0.88) than placebo. In addition, no evidence was found that any of the five vitamins influenced DBP, 24 hours SBP, 24 hours DBP, or HR. The dose of vitamins, geographical region and percentage of males (only SBP) might be sources of heterogeneity. Sensitivity and subgroup analysis revealed that the effect of vitamin intervention on blood pressure varies according to different doses of vitamins.

Conclusion

According to the results, vitamin E might be an effective measure  to reduce SBP, but more research is needed to validate this finding. Prospero Registration Number: CRD42022352332. © Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. Conflict of interest statement: Competing interests: None declared.

References

Qi S(1), Luo X(2), Liu S(1), Ling B(1), Si M(1), Jin H(3). Effect of vitamin B(2), vitamin C, vitamin D, vitamin E and folic acid in adults with essential hypertension: a systematic review and network meta-analysis.  BMJ Open.; 14(1):e074511. doi: 10.1136/bmjopen-2023-074511. Jan 30 2024.