Research: PIRABBASI and COLLEAGUES,

Listed in Issue 253

Abstract

PIRABBASI and COLLEAGUES, 1. Dietetic Programme, Center for Health Care Sciences, Faculty of Allied Health Sciences, Universiti Kebangsaan Malaysia investigated the effect of antioxidant supplementation [ascorbic acid and N-Acetylcysteine (NAC)] on nutritional and antioxidant status in male COPD patients.

Background

Antioxidant therapy has a potential to be introduced as therapeutic modality for chronic obstructive pulmonary disease (COPD) patients.

Methodology

This study aimed to determine the effect of antioxidant supplementation [ascorbic acid and N-Acetylcysteine (NAC)] on nutritional and antioxidant status in male COPD patients. A parallel and single blind randomised controlled clinical trial (RCT) was conducted at two medical centres in Kuala Lumpur, Malaysia. Seventy-nine subjects were recruited and randomly divided into four trial arms (i.e., NAC, vitamin C, NAC+vitamin C and control groups) for six mo. The primary outcome was changes in body mass index by estimating power of 90% and significance level of p<0.05.

Results

Repeated Measure ANOVA showed that there was a significant interaction effect on BMI (p=0.046) and carbohydrate intake (p=0.030), especially in the NAC group. Plasma glutathione (GSH) increased significantly in all intervention groups, especially in vitamin C (p=0.005).

Conclusion

A single supplementation of NAC or vitamin C improved nutritional and antioxidant status of subjects.

References

Pirabbasi E1, Shahar S, Manaf ZA, Rajab NF, Manap RA. Efficacy of Ascorbic Acid (Vitamin C) and/N-Acetylcysteine (NAC) Supplementation on Nutritional and Antioxidant Status of Male Chronic Obstructive Pulmonary Disease (COPD) Patients. J Nutr Sci Vitaminol (Tokyo). 62(1):54-61. doi: 10.3177/jnsv.62.54. 2016.

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