Positive Health Online

Abstract

NOMALI and COLLEAGUES,  (1)Department of Epidemiology and Biostatistics, Tehran University of Medical Sciences, Tehran, Iran. (2)Sue & Bill Gross School of Nursing, University of California Irvine, Irvine, CA. (3) Research Center for Advanced Technologies in Cardiovascular Medicine, Cardiovascular Research Institute, Tehran University of Medical Sciences, Tehran, Iran. (4) Cardiovascular Research Center, Alborz University of Medical Sciences, Karaj, Iran. (5) Department of Pharmacology and Clinical Pharmacology, Horbachevsky Ternopil  National Medical University, Ternopil, Ukraine. (6) Fellowship of Advanced Heart Failure and Transplantation, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. (7) Fellowship of Advanced Heart Failure and Transplantation, Cardiovascular Research Institute, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. (8) Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. (9) Department of Nutrition, Faculty of Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.(10) Department of Pharmacology and Clinical Pharmacology, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine. (11)Ravar Hospital, Kerman University of Medical Sciences, Kerman, Iran. (12)Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran. (13)Department of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. (14) Department of Nutrition, School of Medicine, Zahedan University of Medical  Sciences, Zahedan, Iran. (15)Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. (16) Department of Nutrition and Food Sciences Research Center, Tehran Medical  Sciences, Islamic Azad University, Tehran, Iran.(17) Department of Food and Nutritional Sciences, University of Reading, UK. (18)School of Medicine, Student Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran. (19)Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. conducted a systematic review of clinical trials to study Omega-3 supplementation and outcomes of heart failure.

Background

Omega-3 supplements are endorsed for heart failure (HF) patients to reduce hospitalizations and mortality, offering anti-inflammatory and cardioprotective benefits.

Methodology

A comprehensive search was conducted in various databases until November 2022. Eligible studies included clinical trials on patients with HF. Data extraction covered study details, omega-3 specifics, outcomes, and limitations. The JADAD scale was used to assess the risk of bias in randomized controlled trials.

Results

The review process involved 572 records from database searches, resulting in 19 studies after eliminating duplicates and screening. These studies assessed the impact of omega-3 on various clinical outcomes, such as mortality, hospitalization, cardiac function, and quality of life. Studied duration varied from weeks to years. Omega-3 supplementation demonstrated potential benefits such as improved heart function, reduced inflammation, and decreased risk of cardiovascular events.

Conclusion

Omega-3 supplementation could benefit heart disease treatment, potentially reducing therapy duration and improving outcomes. Starting omega-3 supplementation for HF patients seems favourable. Conflict of interest statement: The authors have no funding and conflicts of interest to disclose. Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.

References

Nomali M(1), Heidari ME(2), Ayati A(3), Tayebi A(4), Shevchuk O(5), Mohammadrezaei R(6), Navid H(7), Khayyatzadeh SS(8)(9), Palii S(10), Valizade Shiran F(11), Khorasanian AS(12), Veysi Z(13), Jamalzehi A(14), Lesani A(15), Assari G(16), Khani S(17), Hassanpour K(18), Gerami H(8)(19). Omega-3 supplementation and outcomes of heart failure: A systematic review of clinical trials. Medicine (Baltimore).;103(3):e36804. DOI: 10.1097/MD.0000000000036804 . Jan 19 2024.

Comment

The above research demonstrated potential benefits such as improved heart function, reduced inflammation, and decreased risk of cardiovascular events and should be introduced into clinical care for heart care.