Research: NOGUEIRA and COLLEAGUES,

Listed in Issue 260

Abstract

NOGUEIRA and COLLEAGUES, 1. Research Center for Micronutrients, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil; 2. Research Center for Micronutrients, UFRJ, Rio de Janeiro, RJ, Brazil; 3. Head of the Parenteral and Enteral Nutrition Therapy Team, Vicente de Paulo Hospital, Rio de Janeiro, RJ, Brazil; 4. Department of Social and Applied Nutrition, Institute of Nutrition, UFRJ, Rio de Janeiro, RJ, Brazil conducted a study to evaluate the state of oxidative stress and levels of serum retinol and β-carotene in patients suffering systemic inflammatory response syndrome (SIRS).

Background

Patients suffering systemic inflammatory response syndrome (SIRS) constitute a group susceptible to elevated levels of oxidative stress. This study's aim is to evaluate the state of oxidative stress and levels of serum retinol and β-carotene in these patients.

Methodology

Forty-six patients were divided into 2 groups: those without diet (G1; n=18) and those with enteral nutritional support (G2; n=28). Serum levels of retinol and total carotenoids were measured. C-reactive protein (CRP) levels and Apache scores were also calculated. Oxidative stress was estimated by measuring thiobarbituric acid reactive substance (TBARS) levels.

Results

The patients' median age was 66.9 (SD=19.3) years. Lower concentrations of retinol and carotenoids were found in 68.6 and 66.7% of G1, respectively. In G2, despite average vitamin A levels being 8078 + 4035, retinol and β-carotene were considered insufficient (31.2 and 33.4%, respectively). No difference was noted between the 2 groups, according to the variables studied, with the exception being PCR and β-carotene (p=0.002; p=0.01).

Conclusion

The data presented in this study supports the need to establish / revise clinical practices in treating SIRS patients, in light of this micronutrient's role in the immune system and antioxidant defence without it interfering with its toxicity.

References

Nogueira C1, Borges F2, Lameu E3, Franca C2, Rosa CL2, Ramalho A4. Retinol, β-carotene and oxidative stress in systemic inflammatory response syndrome.Rev Assoc Med Bras (1992). 61(2):116-20. Mar-Apr 2015. DOI: 10.1590/1806-9282.61.02.116 https://www.ncbi.nlm.nih.gov/pubmed/26107359

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