Research: NISHIZAKI and COLLEAGUES,

Listed in Issue 231

Abstract

NISHIZAKI and COLLEAGUES, (1)Department of Cardiology, Juntendo University Graduate School of Medicine, Tokyo, Japan; (2)Department of Cardiology, Surugadai Nihon University Hospital, Tokyo, Japan; (3)Division of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan; (4)Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; (5)Department of Cardiology, Sempo Takanawa Hospital, Tokyo, Japan; 6)Department of Biostatistics, Graduate School of Public Health, The University of Tokyo, Tokyo, Japan; (7)Division of Cardiology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan; (8)Jichi Medical University, Tochigi, Japan; (9)Department of Cardiology, Juntendo University Graduate School of Medicine, Tokyo, Japan. daida@juntendo.ac.jp assessED the balance of serum n-3 to n-6 polyunsaturated fatty  acids (PUFAs) in patients with acute coronary syndrome (ACS).

Background

Methodology

The author enrolled 1,119 patients who were treated and in whom serum PUFA level was evaluated in 5 divisions of cardiology in a metropolitan area in Japan. Serum levels of PUFAs, including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and arachidonic acid (AA), were compared between patients with and without ACS. They also also evaluated the balance of serum n-3 to n-6 PUFAs, including EPA/AA and DHA/AA ratios.

Results

EPA/AA values were 0.46 ± 0.32 and 0.50 ± 0.32 in the ACS and non-ACS groups, respectively. DHA/AA values were 0.95 ± 0.37 and 0.96 ± 0.41 in the ACS and non-ACS groups, respectively. Next, the authors divided the patients into 3 groups based on the tertiles of EPA/AA or tertiles of DHA/AA to determine the independent risk factors for ACS. According to multivariate logistic regression analysis, the group with the lowest EPA/AA (≤0.33) had a greater probability of ACS (odds ratio 3.14, 95% confidence interval 1.16 to 8.49), but this was not true for DHA/AA.

Conclusion

In conclusion, an imbalance in the ratio of serum EPA to AA, but not in the ratio of DHA to AA, was significantly associated with acute coronary syndrome (ACS).

References

Nishizaki Y(1), Shimada K(1), Tani S(2), Ogawa T(3), Ando J(4), Takahashi M(4), Yamamoto M(5), Shinozaki T(6), Miyauchi K(1), Nagao K(2), Hirayama A(7), Yoshimura M(3), Komuro I(4), Nagai R(8), Daida H(9). Significance of imbalance in the ratio of serum n-3 to n-6 polyunsaturated fatty  acids in patients with acute coronary syndrome. Am J Cardiol. 113(3):441-5. Feb 1 2014. doi: 10.1016/j.amjcard.2013.10.011. Epub Nov 7 2013.

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