Research: NEGGERS and COLLEAGUES,

Listed in Issue 187

Abstract

NEGGERS and COLLEAGUES, Department of Human Nutrition, University of Alabama, Tuscaloosa, Alabama 35487, USA. yneggers@ches.ua.edu case control study was conducted to evaluate the association between plasma fatty acid levels and mental retardation in Korean children.

Background

There is evidence that alteration in plasma fatty acid composition may play a role in certain neurological disorders. This case control study was conducted to evaluate the association between plasma fatty acid levels and mental retardation in Korean children.

Methodology

Plasma phospholipid fatty acids, plasma lipids, dietary fatty acids and selected nutrients were measured in 31 mentally retarded boys (mean age 9.93 +/-1.5 yrs) and matched controls.

Results

Total plasma omega-3 fatty acids (Sigmaw3), docosahexaenoic acid (DHA) and high density lipoprotein (HDL) concentrations were significantly lower and the Sigmaomega-6/Sigmaomega-3 ratio was significantly higher in cases than in controls. The odds in favor of mental retardation increased by 69 % for each unit increase in the Sigmaomega-6/ Sigmaomega-3 ratio (adjusted odds ratio = 1.69, 95% CI = 1.25-2.29). Significant variation in plasma Sigmaomega-3 and the Sigmaomega-6/ Sigmaomega-3 ratio was explained by mental retardation and plasma HDL concentrations (45% and 37 % respectively). There was a significant inverse association between plasma DHA and mental retardation. For each unit increase in plasma DHA, odds of mental retardation decreased by 74 %. There was no significant difference in either total dietary fat or fatty acids intakes between cases and controls. The energy intake of cases was significantly higher than the controls.

Conclusion

These results suggest that proportion of plasma Sigmaomega-3 fatty acids, particularly, DHA, and the Sigmaomega-6/ Sigmaomega-3 ratio are associated with mental retardation in children in this study.

References

Neggers YH, Kim EK, Song JM, Chung EJ, Um YS and Park T. Mental retardation is associated with plasma omega-3 fatty acid levels and the omega-3/omega-6 ratio in children. Asia Pacific Journal of Clinical Nutrition. 18(1):22-8. 2009.

Munro Hall Clinic 2019

IJCA 2018 New Skyscraper

Scientific and Medical Network 2

Cycle India 2020

Walk on the Wide Side Trek Kenya 2020

Big Heart Bike Ride South Africa 2020

Scientific and Medical Network 2021

top of the page