Research: NAZEMINEZHAD and COLLEAGUES

Listed in Issue 237

Abstract

NAZEMINEZHAD and COLLEAGUES (1)Biochemistry of Nutrition Research Center, School of Medicine, Mashhad University of Medical Science, Mashhad, Iran; (2)1] Health Sciences Research Center, Department of Health and Management, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran [2] Department of Community Health, Faculty of Medicine and Health Sciences, University Putra Malaysia, Selangor, Malaysia; (3)Department of Community Health, Faculty of Medicine and Health Sciences, University Putra Malaysia, Selangor, Malaysia; (4)Cardiovascular Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; (5)Department of Biostatistics, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran.

(6)Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex BN1 9PH, UK; (7)1] Biochemistry of Nutrition Research Center, School of Medicine, Mashhad University of Medical Science, Mashhad, Iran [2] Cardiovascular Research Center,  School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; (8)Student Research Committee, Department of Modern Sciences and Technologies, School of Medicine, Mashhad University of Sciences, Mashhad, Iran studied the relationship between dietary intake and biomarkers of cardiovascular risk.

Background

The aim of this study was to investigate the relationship between dietary intake and biomarkers of cardiovascular risk in individuals with and without angiographically defined coronary artery disease (CAD).

Methodology

Coronary angiography was undertaken in 445 individuals who were divided into those with significant disease (>50% occlusion) (Angio+ (n=273)) and those with <50% coronary artery occlusion (Angio- (n=172)). Apparently healthy, non-symptomatic individuals (n=443) were considered as the control group. Dietary intake was assessed using a 24-h dietary recall method and dietary analysis was performed using Diet Plan 6 software.

Results

Concentrations of starch, saturated fatty acids, polyunsaturated fatty acids, magnesium, iron and copper in the control group were less than those in the other groups (P<0.05), but after adjusting for total energy intake these differences were no longer apparent. The mean intake of protein, cholesterol, phosphorus, zinc, zinc/copper ratio, selenium, iodine, carotene, vitamin E, niacin, pantothene and pyridoxine was less in the control group compared with the other two groups (P<0.05), and the mean of sugar, fibre, trans fatty acids, manganese, folate and vitamin C was higher in the control group than in other groups (P<0.05). Lipid profile values between the three groups did not differ significantly.

Conclusion

These results indicate that the amount of intake of various nutrients can be considered as an independent risk factor for CAD. Further research on the relationship between CAD and nutrient intake, especially intake of essential micronutrients, is needed.

References

Nazeminezhad R(1), Tajfard M(2), Latiff LA(3), Mouhebati M(4), Esmaeily H(5), Ferns GA(6), Ghayour-Mobarhan M(7), Rahimi HR(8). Dietary intake of patients with angiographically defined coronary artery disease  and that of healthy controls in Iran.  Eur J Clin Nutr. 68(1):109-13. doi: 10.1038/ejcn.2013.205. Jan 2014. Epub Nov 13 2013.

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