Positive Health Online

Abstract

MUNDT and COLLEAGUES,  (1)Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; (2)Center for Circadian and Sleep Medicine, Northwestern University Feinberg  School of Medicine, Chicago, IL, USA; (3)Department of Psychology, Indiana University Indianapolis, Indianapolis, IN, USA; (4)Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; (5)Division of Advanced Nursing Practice and Science, University of Arizona College of Nursing, Tucson, AZ, USA; (6)Department of Psychological and Brain Sciences, Indiana University Bloomington, Bloomington, IN, USA; (7)Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, GA, USA; (8)Nox Health, Inc., Alpharetta, GA, USA. Comment in     Sleep. ;47(10):zsae166. doi: 10.1093/sleep/zsae166. Oct 11 2024 examined the feasibility and acceptability of an Mindfulness-based interventions (MBI) that was adapted for narcolepsy,

Background

Methodology

Study Objectives: Mindfulness-based interventions (MBI) have been shown to improve psychosocial functioning in medical populations but have not been studied in narcolepsy. This study examined the feasibility and acceptability of an MBI that was adapted for narcolepsy, including three variations in program length. Adults with narcolepsy (N = 60) were randomized to MBI groups of varying durations: brief (4 weeks), standard (8 weeks), or extended (12 weeks). Participants completed assessments at baseline, 4, 8, and 12 weeks. To assess feasibility and acceptability, primary outcomes included attendance, meditation practice, and data completeness. Additionally, participants completed measures of mindfulness, self-compassion, mood, sleep, psychosocial functioning, and cognition. An effect size of Cohen's d ≥ 0.5 was used as the prespecified benchmark for a minimal clinically important difference (MCID).

Results

The attendance, meditation, and data completeness benchmarks were met by 71.7%, 61.7%, and 78.3% of participants, respectively. Higher proportions of the brief and extended groups met these benchmarks compared to the standard group. All groups met the MCID for mindfulness, self-compassion, self-efficacy for managing emotions, positive psychosocial impact, global mental health, and fatigue. Standard and extended groups met the MCID for anxiety and depression, and extended groups met the MCID for additional measures including social and cognitive functioning, daytime sleepiness, hypersomnia symptoms, and hypersomnia-related functioning.

Conclusion

Results suggest that the remote delivery and data collection methods are feasible to employ in future clinical trials, and it appears that the extended MBI provides the most favourable clinical impact while maintaining attendance and engagement in meditation practice. Clinical Trial Registration: Awareness and Self-Compassion Enhancing Narcolepsy Treatment (ASCENT), NCT04306952, https://clinicaltrials.gov/ct2/show/NCT04306952.  © The Author(s) 2024. Published by Oxford University Press on behalf of Sleep Research Society. All rights reserved. For commercial re-use, please contact reprints@oup.com  for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site – for further information please contact journals.permissions@oup.com.

References

Mundt JM(1)(2), Zee PC(1)(2), Schuiling MD(3), Hakenjos AJ(1), Victorson DE(4), Fox RS(4)(5), Dawson SC(6), Rogers AE(7), Ong JC(1)(2)(8). Development of a mindfulness-based intervention for narcolepsy: a feasibility study.  Sleep.  ;47(10):zsae137. doi: 10.1093/sleep/zsae137. Oct 11 2024.