Positive Health Online

Abstract

MARZAGALLI and COLLEAGUES, (1)Department of Pharmacological and Biomolecular Sciences "Rodolfo Paoletti University of Milano, Milano 20133, Italy; (2)R&D Department Kolinpharma S.p.A., Lainate 20045, Italy; (3)Department of Earth and Environmental Sciences University of Pavia, Pavia 27100, Italy analyzed the efficacy of a novel combination of these compounds (Mix) in counteracting proinflammatory (IL-1β) and prooxidant (H2O2) stimuli in human tenocytes.

 

Background

Tendinopathy is one of the most frequent musculoskeletal disorders characterized by sustained tissue inflammation and oxidative stress, accompanied by extracellular matrix remodelling. Patients suffering from this pathology frequently experience pain, swelling, stiffness, and muscle weakness.

Methodology

Current pharmacological interventions are based on nonsteroidal anti-inflammatory drugs; however, the effectiveness of these strategies remains ambiguous.

Results

Accumulating evidence supports that oral supplementation of natural compounds can provide preventive, and possibly curative, effects. Vitamin C (Vit C), collagen peptides (Coll), resveratrol (Res), and astaxanthin (Asx) were reported to be endowed with potential beneficial effects based on their anti-inflammatory and antioxidant activities. Here, we analyzed the efficacy of a novel combination of these compounds (Mix) in counteracting proinflammatory (IL-1β) and prooxidant (H2O2) stimuli in human tenocytes. We demonstrated that Mix significantly impairs IL-6-induced IL-1β secretion, NF-κB nuclear translocation, and MMP-2 production; notably, a synergistic effect of Mix over the single compounds could be observed.

Conclusion

Moreover, Mix was able to significantly counteract H2O2-triggered ROS production. Together, these results point out that Mix, a novel combination of Vit C, Coll, Resv, and Asx, significantly impairs proinflammatory and prooxidant stimuli in tenocytes, mechanisms that contribute to the onset of tendinopathies. Copyright © 2024 Monica Marzagalli et al. Conflict of interest statement: Dr. Stefania Battaglia, Dr. Marco Cozzi, Dr. Francesca R. Ranieri, and Dr. Valeria Curti are employees of Kolinpharma S.p.A., a nutraceutical company that produces and commercializes food supplements. These authors report no involvement of the company in the research that could have influenced the outcome of this work. The other authors declare that there is no conflict of interest regarding the publication of this article.

References

Marzagalli M(1), Battaglia S(2), Raimondi M(1), Fontana F(1), Cozzi M(2), Ranieri FR(2), Sacchi R(3), Curti V(2), Limonta P(1). Anti-Inflammatory and Antioxidant Properties of a New Mixture of Vitamin C, Collagen Peptides, Resveratrol, and Astaxanthin in Tenocytes: Molecular Basis for Future Applications in Tendinopathies. . Mediators Inflamm. ;2024:5273198. doi: 10.1155/2024/5273198.  2024 Jul 30. eCollection 2024.