Positive Health Online

Abstract

LI and COLLEAGUES,  (1)Department of Pulmonary and Critical Care Medicine, Shaoxing People's Hospital, Shaoxing312000, Zhejiang, People's Republic of China; (2)Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou325000, Zhejiang, People's Republic of China sought to investigate the association between n-3 PUFA and lung function

Background

This study aimed to investigate the association between n-3 PUFA and lung function.

Methodology

First, a cross-sectional study was conducted based on the National Health and Nutrition Examination Survey (NHANES) 2007-2012 data. n-3 PUFA intake was obtained from 24-h dietary recalls. A multivariable linear regression model was used to assess the observational associations of n-3 PUFA intake with lung function. Subsequently, a two-sample Mendelian randomisation (MR) was performed to estimate the potential causal effect of n-3 PUFA on lung function. Genetic instrumental variables were extracted from published genome-wide association studies. Summary statistics about n-3 PUFA was from UK Biobank. Inverse variance weighted was the primary analysis approach.

Results

The observational study did not demonstrate a significant association between n-3 PUFA intake and most lung function measures; however, a notable exception was observed with significant findings in the highest quartile for forced vital capacity (FVC) and % predicted FVC. The MR results also showed no causal effect of circulating n-3 PUFA concentration on lung function (forced expiratory volume in one second (FEV1), β = 0·01301, se = 0·01932, P = 0·5006; FVC, β = -0·001894, se = 0·01704, P = 0·9115; FEV1:FVC, β = 0·03118, se = 0·01743, P = 0·07359).

Conclusion

These findings indicate the need for further investigation into the impact of higher n-3 PUFA consumption on lung health.

References

Li J(1), Sun J(1), Liu L(2), Zhang C(1), Liu Z(1). Association between n-3 PUFA and lung function: results from the NHANES 2007-2012 and Mendelian randomisation study. Br J Nutr.;131(10):1720-1729. doi: 10.1017/S0007114524000266. Epub Jan 26 2024 . May 28 2024.