Research: KAUL and colleagues, D

Listed in Issue 28

Abstract

KAUL and colleagues, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, USA, have reviewed (100 references) the literature on the use of alpha-tocopherol (Vitamin E) in the prevention of cardiovascular disease.

Background

There is compelling evidence for the role of oxidative stress in the pathogenesis of atherosclerotic lesions, and several lines of evidence suggest that antioxidants, particularly alpha-tocopherol, have potential beneficial effects on cardiovascular disease.

Methodology

Literature review.

Results

In vitro data are compelling to show that alpha-tocopherol inhibits platelet aggregation and smooth muscle cell proliferation, exerts anti-inflammatory effects on monocytes, and improves endothelial function. However clinical trials with the substance have to date been equivocal.

Conclusion

Although the evidence from in vitro studies is convincing, further clinical trials of alpha-tocopherol are necessary before definitive recommendations can be made about its use in the prevention of cardiovascular disease.

References

Kaul N, Devaraj S, Jialal I. Alpha-tocopherol and atherosclerosis. Experimental Biology and Medicine 226 (1) : 5-12. Jan 2001.

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