Research: KAUL and colleagues, D

Listed in Issue 28


KAUL and colleagues, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, USA, have reviewed (100 references) the literature on the use of alpha-tocopherol (Vitamin E) in the prevention of cardiovascular disease.


There is compelling evidence for the role of oxidative stress in the pathogenesis of atherosclerotic lesions, and several lines of evidence suggest that antioxidants, particularly alpha-tocopherol, have potential beneficial effects on cardiovascular disease.


Literature review.


In vitro data are compelling to show that alpha-tocopherol inhibits platelet aggregation and smooth muscle cell proliferation, exerts anti-inflammatory effects on monocytes, and improves endothelial function. However clinical trials with the substance have to date been equivocal.


Although the evidence from in vitro studies is convincing, further clinical trials of alpha-tocopherol are necessary before definitive recommendations can be made about its use in the prevention of cardiovascular disease.


Kaul N, Devaraj S, Jialal I. Alpha-tocopherol and atherosclerosis. Experimental Biology and Medicine 226 (1) : 5-12. Jan 2001.

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