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Research: JAIN and colleagues, D
Listed in Issue 86
Abstract
JAIN and colleagues, Department of Medicine, MAMC and Associated Lok Nayak and GB Pant Hospitals, New Delhi, describe the effects of low-dose omega-3 fatty acid substitution in type 2 diabetes .
Background
A state of increased oxidative stress has been recognized in type 2 diabetes mellitus . This study was done in order to assess the effects of omega-3 fatty acids on this state of oxidative stress .
Methodology
In this prospective preliminary study, 65 patients with type 2 diabetes mellitus and 30 healthy controls were evaluated for blood glucose, blood pressure, lipid profile, and oxidative stress (as measured by lipid peroxides, diene conjugates, and reduced glutathione in serum). 40 diabetes patients were randomly divided into two groups . One group were prescribed a diabetic diet plus a placebo . The other group were prescribed a diabetic diet plus 180 mg of eicosapentaenoic acid and 120 mg of docosahexaenoic acid twice daily . After 6 weeks all parameters were reassessed.
Results
The measured biochemical parameters showed a significant elevation of oxidative stress in the type 2 diabetes patients as compared to healthy controls. After 6 weeks, the oxidative stress parameters had improved in both groups but significantly more so in the omega-3 fatty acids group . Patients in this group also showed better values for glycaemic status, blood pressure and lipid profile.
Conclusion
This study shows that people suffering from type 2 diabetes mellitus are exposed to elevated oxidative stress which can be improved by addition of low levels of omega-3 fatty acids to their diet . Moreover, blood pressure and metabolic profile improve under such a regimen.
References
Jain S, Gaiha M, Bhattacharjee J, Anuradha S, et al. Effects of low-dose omega-3 fatty acid substitution in type-2 diabetes mellitus with special reference to oxidative stress: a prospective preliminary study. Journal of the Association of Physicians of India 50: 1028-1033, Aug 2002.
