Positive Health Online

Abstract

HUANG and COLLEAGUES, (1)Department of Dermatology & STD, the Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.; (2)Department of Dermatology, Suining First People's Hospital, Suining, Sichuan, China. (3)Department of Dermatology, Chengdu Fifth People's Hospital, Chengdu, Sichuan, China. (4)Department of Endocrinology and Metabolism, The Affiliated Hospital of  Southwest Medical University, Luzhou, Sichuan, China. (5)Cardiovascular and Metabolic Diseases Key Laboratory of Luzhou, Luzhou, Sichuan, China.; (6)Sichuan Clinical Research Center for Nephropathy, Luzhou, Sichuan, China. (7)Metabolic Vascular Disease Key Laboratory of Sichuan Province, Luzhou, Sichuan, China set out to explore the potential role of omega-3 (ω-3) fatty acids on acne vulgaris by modulating gut microbiota.

Background

The authors aimed to explore the potential role of omega-3 (ω-3) fatty acids on acne vulgaris by modulating gut microbiota.

Methodology

The authors randomly divided the untreated acne patients into two groups with or without ω-3 fatty acids intervention for 12 weeks. The Sprague Dawley (SD) rats with acne model were given isotretinoin, ω-3 fatty acids or their combination respectively. Then the colonic contents samples of the drug intervention SD rats were transferred to the pseudo sterile rats with acne model. The severity of the disease was assessed by the Global Acne Grading System (GAGS) score of the patients, and the swelling rate of auricle and the pathological section of the rat with acne model. The 16S rDNA gene sequencing was performed to detect the alteration of the gut microbiota.

Results

ω-3 fatty acids could increase the diversity of the gut microbiota and regulate the flora structure positively both in the patients and rats, increase the abundance of butyric acid producing bacteria and GAGS score in the patients, and alleviate the inflammation and comedones [small, flesh-coloured, white, or dark bumps that give skin a rough texture]of rats.

Conclusion

Supplementation of ω-3 fatty acids could alleviate the inflammation of acne vulgaris by increasing the abundance of butyric acid producing bacteria.

References

Huang Y(1), Liu F(1), Lai J(2), Jiang S(3), Tan X(1), Chen L(1), Xu Y(4)(5)(6)(7), Xiong X(1), Deng Y(1). The adjuvant treatment role of ω-3 fatty acids by regulating gut microbiota positively in the acne vulgaris.  J Dermatolog Treat. ;35(1):2299107. https://doi.org/10.1080/09546634.2023.2299107. Epub 2024 Jan 2. Dec 2024.