Listed in Issue 221


DiNICOLANTONIO and COLLEAGUES,  Mid America Heart Institute, Saint Luke's Hospital, Kansas City, USA. , Heart Hospital, University College London Hospitals UCLH, London-UK. Mid America Heart institute at Saint Luke's Hospital and University of Missouri-Kansas City, Kansas City, USA evaluate and explore whether there may be further explanations in recent omega-3 trials to explain why recent trials testing omega-3s have not confirmed their benefits in coronary heart disease CHD.


Multiple trials over the past two decades testing omega-3 polyunsaturated fatty acids (PUFAs), containing eicosapentaenoic acid (EPA) and or docosahexaenoic acid (DHA), have shown substantial benefits for reducing major coronary heart disease (CHD) events, all-cause mortality, cardiovascular (CV) death, sudden cardiac death (SCD), and stroke.


However, recent trials testing omega-3s have generally failed to confirm these benefits.


While increased fish and fish oil intake among the general population, increased use of optimal medical therapy (including statins, aspirin, and modern antihypertensive medications) probably make it more challenging for fish oil supplementation to show additional benefits, there might be further explanations in the formulation, dosage, and comparator used in these recent omega-3 trials.



DiNicolantonio JJ, Meier P and O'Keefe JH. Omega-3 polyunsaturated fatty acids for the prevention of cardiovascular disease: do formulation, dosage & comparator matter? Mo Med. Nov-Dec 2013.110(6): 495-8.

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