Positive Health Online

Abstract

DAS and COLLEAGUES, (1)Department of Pathology, Shri B. M. Patil Medical College, Hospital and Research Centre, BLDE (Deemed to be University), Vijayapur, Karnataka, India.(2)Laboratory of Vascular Physiology and Medicine, Department of Physiology, Shri B. M. Patil Medical College, Hospital and Research Centre, BLDE (Deemed to be University), Vijayapur, Karnataka, India.

 

Background

Liver diseases are complex conditions, significantly influenced by oxidative stress

Methodology

This comprehensive review assesses the therapeutic role of antioxidants like l-ascorbic acid and α tocopherol, beta-carotene, various minerals, and plant-based ingredients in mitigating oxidative stress-induced liver diseases. The manuscript delves into the critical influence of genetic and epigenetic factors on disease susceptibility, progression, and response to antioxidant therapy.

Results

While animal studies suggest antioxidant efficacy in liver disease treatment, human trials remain inconclusive, and caution is advised due to its possible potential pro-oxidant effects. Moreover, the interactions of antioxidants with other drugs necessitate careful consideration in the management of polypharmacy in liver disease patients. The review underscores the need for further research to establish the clinical benefits of antioxidants with understanding of possible antioxidant toxicities to elucidate the intricate interplay of genetic, epigenetic, and environmental factors in liver diseases.

Conclusion

The aim is to foster a better understanding of the knowledge on hepatic disease management with judicial antioxidant therapies. © 2024 Walter de Gruyter GmbH, Berlin/Boston.

References

Das SK(1), Nerune SM(1), Das KK(2). Antioxidant therapy for hepatic diseases: a double-edged sword.  J Basic Clin Physiol Pharmacol.;35(1-2):7-14. eCollection Jan 1 2024 . Jan 19 2024. doi: 10.1515/jbcpp-2023-0156.