Research: BARTFAY and colleagues,

Listed in Issue 41

Abstract

BARTFAY and colleagues, Centre for Cardiovascular Research, Toronto Hospital, Ontario Canada review the literature (47 references) and set out to determine whether vitamin E and selenium supplementation can improve myocardial antioxidant defences in mouse hearts overloaded with iron.

Background

Methodology

Iron dextran was injected (5 mg intraperitoneally/mouse) daily into B6D2F1 mice (n = 20). The mice were also randomly assigned to simultaneously receive either: 1) vitamin E, 40 mg intraperitoneally, n = 5; 2) selenium (sodium selenite, 1 part/million orally, n = 5); 3) both vitamin E and selenium, n = 5, or 4) iron-only treatment, n = 5. In a subsequent study, 15 B6D2F1 mice were randomly assigned to receive daily injections of iron (n = 5), or iron plus combined antioxidants (vitamin E and selenium, n = 5, or to act as controls, n = 5 for 4 weeks.

Results

Compared to iron-only treated or single supplemented mice, there were significantly greater concentrations of heart selenium and glutathione peroxidase activity in mice supplemented with both vitamin E and selenium. Additionally, compared to mice receiving iron-only treatment, there were significantly lower concentrations of iron found in controls and in those receiving combined iron and antioxidant treatment of vitamin E and selenium.

Conclusion

Vitamin E and selenium act synergistically within the myocardium to provide key antioxidant defences in iron-overload states, including increased concentrations of selenium, increased glutathione peroxidase activity and decreased iron concentrations.

References

Bartfay WJ et al. The synergistic effects of vitamin E and selenium in iron-overloaded mouse hearts. Can J Cardiol 14(7): 937-41 Jul 1998.

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