Research: ASHA DEVI

Listed in Issue 180

Abstract

ASHA DEVI,  Laboratory of Gerontology, Department of Zoology, Bangalore University, Bangalore 560 056, India. asuba@blr.vsnl.net.in reviews [48 references] research the effects of antioxidant supplements and physical activity upon cognitive decline in older people.

Background

With ageing, the brain undergoes neuronal loss in many areas.

Methodology

Although the loss of cells in the cerebral cortex, in particular the frontal cortex, has been recognized with ageing, the influence of synaptic losses has a larger impact on cognitive decline.

Results

Much of the recent research on animals, as well as humans, has been aimed at slowing the cognitive decline through enrichment, and it has been found that the key factors are antioxidants and exercise. Several reports support the concept that regular supplementation of vitamin E and physical activity from as early as middle age can slow the cognitive decline observed during the later years. A few studies have also suggested that exercise is analogous to acetylcholine esterase inhibitors that are also used extensively to treat cognitive impairment and dementia in Alzheimer's disease.

Conclusion

In addition, reports also support that vitamin E and exercise may act synergistically to overcome free radical injury and oxidative stress in the aging brain. [References: 48]

References

Asha Devi S. Aging brain: prevention of oxidative stress by vitamin E and exercise. [Review] [48 refs] Thescientificworldjournal, 9: 366-72. 2009.

Comment

These suggested supplements and exercise may prove to be more important as the population ages and is more subjected to cognitive decline.

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