Research: ADAMS and colleagues,

Listed in Issue 28


ADAMS and colleagues, University of Wisconsin Medical School, Madison 53792-3248 USA reviews (46 references) the literature regarding how the use of antioxidant vitamins may help to prevent coronary heart disease (CHD).




Epidemiological studies have found lower CHD morbidity and mortality in individuals consuming larger quantities of antioxidants in foods or supplements. Clinical trials have indicated that supplementation with certain nutrients is beneficial in reducing incidence of CHD events and recent studies have shown that supplementation with antioxidant vitamins E and C have benefits regarding CHD prevention. Supplementation with beta-carotene may have deleterious effects and is not recommended. Current research evidence suggests that CHD patients would benefit from taking vitamin E at a dose of 400 IU daily and vitamin C at a dosage of 500-1000 mg per day. Clinicians may also wish to consider vitamin supplementation for CHD prevention in high-risk patients. Folate decreases elevated homocysteine levels; however there is no evidence yet for routine supplemental use with folate.



Adams AK et al. Antioxidant vitamins and the prevention of coronary heart disease. American Family Physician 60(3): 895-904. 1 Sep 1999.

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