Positive Health Online

Abstract

ABUDU and co-workers, Department of Pathology and Laboratory Medicine, University of Louisville, 40292, Louisville, KY, USA, have reviewed (149 references) vitamins in human atherosclerosis, particularly vitamins C and E. Abstract: This review focuses on the process of atherosclerosis arising from oxidative stress on lipoproteins, and the general failure of randomized human trials using vitamins to retard this process. The paper reviews the mechanisms by which a variety of oxidants act, as well as interactions between supplemental or co-antioxidants that counterbalance pro-oxidant effects of one another. It is concluded that normal cellular supplementation mechanisms are poorly accessible in the atherosclerotic plaque so that an oxidative environment is created. Haphazard introduction of antioxidant vitamins into this environment could even be dangerous. It is to be hoped that approaches will be developed whereby antioxidants can be introduced into tissue in more controlled fashion and reduce atherosclerosis.

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References

Abudu N, Miller JJ, Attaelmannan M, Levinson SS. Vitamins in human arteriosclerosis with emphasis on vitamin C and vitamin E. Clinica Chimica Acta 339 (1-2): 11-25, Jan 2004.