Research: YU and COLLEAGUES,

Listed in Issue 250

Abstract

YU and COLLEAGUES, 1. Department of Respiratory Medicine, The First Hospital of China Medical University, No.155 Nanjing North Street, He-ping District, Shenyang 110001, Liaoning, China. nayu888@yeah.net; 2. Department of Respiratory Medicine, The First Hospital of China Medical University, No.155 Nanjing North Street, He-ping District, Shenyang 110001, Liaoning, China. xinmingsu123@yeah.net ; 3. Department of Respiratory Medicine, The First Hospital of China Medical University, No.155 Nanjing North Street, He-ping District, Shenyang 110001, Liaoning, China. zanfengwang123@yeah.net ; 4. Department of Respiratory Medicine, The First Hospital of China Medical University, No.155 Nanjing North Street, He-ping District, Shenyang 110001, Liaoning, China. bingdai123@yeah.net ;5. Department of Respiratory Medicine, The First Hospital of China Medical University, No.155 Nanjing North Street, He-ping District, Shenyang 110001, Liaoning, China kangjian58@163.com conducted a meta-analysis to investigate the association between dietary β-carotene and vitamin A intake and protection against lung cancer risk.

Background

Whether dietary β-carotene and vitamin A intake protect against lung cancer risk is not clear.

Methodology

Therefore, the authors performed this meta-analysis to investigate the association between them. The related articles were searched using the databases PubMed and the Web of Knowledge up to May 2015. We used the random-effect model to estimate the relative risk (RR) and their 95% CI. Small-study effect was assessed using Egger's test. In total, 19 studies comprising 10,261 lung cancer cases met the inclusion criteria.

Results

The pooled RR and their 95% CI was 0.855 (0.739-0.989) for higher category of dietary vitamin A intake and lung cancer risk, especially among Asian populations and in the cohort studies. Evidence from 18 studies suggested that higher category of dietary β-carotene intake could reduce lung cancer risk (0.768 (0.675-0.874)).The associations were also significant in American and Asian populations.

Conclusion

In conclusions, higher category of dietary β-carotene and vitamin A intakes could reduce the risk of lung cancer. However, the dose-response analysis was not performed due to the limited data in each individual study. Due to this limitation, further studies with detailed dose, cases and person-years for β-carotene and vitamin A of each category are wanted to assess this dose-response association.

References

Yu N1, Su X2, Wang Z3, Dai B4, Kang J5. Association of Dietary Vitamin A and β-Carotene Intake with the Risk of Lung Cancer: A Meta-Analysis of 19 Publications. Nutrients. 7(11): 9309-24. doi: 10.3390/nu7115463. Nov 11 2015.

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