Research: YANG and COLLEAGUES,

Listed in Issue 248


YANG and COLLEAGUES, (1)Department of Nutrition, I-Shou University, Kaohsiung 824, Taiwan, ROC. (2)School of Nutrition and Health Sciences, Taipei Medical University, Taipei 110, Taiwan, ROC set out to study in hypertensive rats, the effects of β-conglycinin (one of the major storage proteins of soybeans) and soya isoflavones on diabetic nephropathy (DN).


The objective of the present study was to investigate the effects of β-conglycinin and soya isoflavones on diabetic nephropathy (DN).


DN was induced by an intravenous injection of streptozotocin (25 mg/kg) in spontaneously hypertensive rats. DN rats were divided into a non-diabetic group (C, control group) and three DN groups (D, DN with control diet; B, DN+control diet with one-eighth of casein replaced by β-conglycinin as the protein source; and I, DN+control diet with 0·01 % soya isoflavones).


After a 4-week experimental period, the authors found that fasting blood sugar and plasma and kidney advanced glycation end product levels and 24 h urinary protein excretion of the B group were significantly lower than those of the D group and insulin sensitivity and nephrin expression of the B group were significantly higher than those of the D group. In addition, systolic blood pressure, angiotensin-converting enzyme activity, angiotensin II level and plasma TAG level of the B group were significantly lower than those of the D group, whereas only the levels of plasma TAG and thiobarbituric acid-reactive substances of the I group were lower than those of the D group.


In conclusion, β-conglycinin may be beneficial for retarding DN progression and this effect cannot be completely explained by its isoflavone content.


Yang HY(1), Wu LY(2), Yeh WJ(2), Chen JR(2). Beneficial effects of β-conglycinin on renal function and nephrin expression in early streptozotocin-induced diabetic nephropathy rats.  Br J Nutr. 111(1):78-85. Jan 14 2014. doi: 10.1017/S0007114513001876. Epub 2013 Jun 27.

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