Research: WENDELL and COLLEAGUES,

Listed in Issue 221

Abstract

WENDELL and COLLEAGUES, Asthma Institute, UPMC, Department of Medicine, Pittsburgh, Pa. Asthma Institute, UPMC, Department of Medicine, Pittsburgh, Pa. Electronic address: feh9@pitt.edu review the role of fatty acid inflammatory mediators to summarize the data regarding how diet and obesity alter fatty acid profiles that may contribute to asthma.

Background

Fatty acids and consequently diet play an essential role in the formation of inflammatory mediators involved in the pathogenesis of asthma.

Methodology

Because intake variations of omega-6 (n-6) and omega-3 (n-3) fatty acids ultimately determine cell membrane incorporation, changes in diet have the potential to modify downstream production of inflammatory mediators derived from these compounds.

Results

It has long been hypothesized that decreasing the n-6/n-3 ratio could reduce the production of more pro-inflammatory mediators while increasing the formation of downstream metabolites that can serve to limit or resolve inflammation. In turn, these changes would result in improved asthma outcomes or would lower the risk for asthma incidence.

Conclusion

This review will focus on the role of fatty acid inflammatory and resolving mediators and will summarize the clinical and epidemiologic data on how diet and obesity alter fatty acid profiles that can contribute to asthma.

References

Wendell SG, Baffi C and Holguin F. Fatty acids, inflammation, and asthma. J Allergy Clin Immunol.;133(5):1255-64. doi: 10.1016/j.jaci.2013.12.1087. Epub. Mar 7 2014. May 2014.

Comment

The results of this review, when published, will provide credible and important information regarding the role of diet, including essential fatty acids and obesity and their potential contributions to asthma.

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