Positive Health Online

Abstract

WEN and COLLEAGUES, (1)State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau; (2) Centre for Regenerative Medicine and Health, Hong Kong Institute of Science & Innovation, Chinese Academy of Sciences, Hong Kong Science Park, Hong Kong; (3)An-Nan Hospital, China Medical University, Tainan, Taiwan; Department of Psychiatry, China Medical University Hospital, Taichung, Taiwan; Mind-Body Interface Research Center (MBI-Lab), China Medical University Hospital, Taichung, Taiwan.  cobol@cmu.edu.tw ; (4)State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau. huanxingsu@um.edu.mo  explore and review the. underlying mechanisms that contribute to the beneficial effects of n-3 PUFAs against AD and dementia

Background

Alzheimer's disease (AD) and other forms of dementia represent major public health challenges but effective therapeutic options are limited. Pathological brain ageing is associated with microvascular changes and impaired clearance systems.

Methodology

The application of omega-3 polyunsaturated fatty acids (n-3 or omega-3 PUFAs) is one of the most promising nutritional interventions in neurodegenerative disorders from epidemiological data, clinical and pre-clinical studies.

Results

As essential components of neuronal membranes, n-3 PUFAs have shown neuroprotection and anti-inflammatory effects, as well as modulatory effects through microvascular pathophysiology, amyloid-beta (Aβ) clearance and glymphatic pathways.

Conclusion

This review meticulously explores these underlying mechanisms that contribute to the beneficial effects of n-3 PUFAs against AD and dementia, synthesizing evidence from both animal and interventional studies.. Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved. Conflict of interest statement: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

References

Wen J(1), Satyanarayanan SK(2), Li A(1), Yan L(1), Zhao Z(1), Yuan Q(2), Su
KP(3), Su H(4). Unravelling the impact of Omega-3 polyunsaturated fatty acids on blood-brain barrier (BBB) integrity and glymphatic function. Brain Behav Immun.;115:335-355. doi: 10.1016/j.bbi.2023.10.018. Epub Oct 31 2023 . Jan 2024.