Research: WANG and co-workers,

Listed in Issue 134

Abstract

WANG and co-workers, Department of Acup-Moxibustion, Orthopedics and Traumatology, Wuhan 430061, China, have studied the effects of acupuncture on nerve stem cells in rats with Parkinson’s disease.

Background

The aim of this study was to explore the mechanism of acupuncture in treatment of Parkinson’s disease.

Methodology

50 Wistar rats were randomly divided into a normal control group, a sham-operation control group, a model group, a Fengfu-Taichong group and a Shuanggu Yitong group. The hemilateral rotation Parkinson’s disease model was prepared by micro-injection of 6-hydroxyl-dopamine into the right striatum. The effects of acupuncture at “Fengfu” (GV 16), “Taichong” (LR 3) hy Shoanggu Yitong needling method on proliferation and differentiation of nerve stem cells in the Parkinson’s disease model rat were compared. Proliferation and number changes of the nerve stem cells in the substantia nigra and the striatum were investigated with immunohistochemical methods.

Results

In the two acupuncture groups, the proliferative cells in the substantia nigra and the striatum of the destroyed side increased significantly (p < 0.01). The number of nerve stem cells and the number of transformed neurons in the destroyed side of the substantia nigra and the striatum increased significantly only in the Shuanggu Yitong group (p < 0.01).

Conclusion

The Shuanggu Yitong needling method can induce proliferation and differentiation of nerve stem cells in the substantia nigra and the striatum regions in this animal model of Parkinson’s disease.

References

Wang YC, Ma J, Wang H. Effects of Shuanggu Yitong needling method on proliferation and differentiation of nerve stem cells in the Parkinson’s disease model rat. Zhongguo Zhenjiu 26 (4): 277-282, Apr 2006.

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