Research: VASILJEVIC and COLLEAGUES,

Listed in Issue 271

Abstract

VASILJEVIC and COLLEAGUES, 1. Department of Hygiene, Institute for Public Health, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia; 2. Department of Rheumatology, Internal Clinic, Clinical Center Kragujevac, Kragujevac, Serbia; 3. Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia; 4. Centre of Research Excellence in Nutrition and Metabolism, Institute of Medical Research, University of Belgrade, Belgrade, Serbia; 5. Department of Medical Sciences, Faculty for Tourism, University of Kragujevac, Vrnjacka Banja, Serbia; 6. Institute of Medical Physiology "Richard Burian," Faculty of Medicine, University of Belgrade, Belgrade, Serbia; 7. Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, 69 Svetozara Markovica, 34000, Kragujevac, Serbia. drvladakgbg@yahoo.com evaluated the effects of different supplementation on oxidative status in patients with rheumatoid arthritis

Background

Rheumatoid arthritis is a chronic inflammatory disease. Reactive oxygen species have been considered as aggravating factors for autoimmune diseases. Fatty acids had been linked in reduction of various diseases by augment of their antioxidant potential and anti-inflammatory mechanisms.

Methodology

The aim of this study was to assess the oxidative status in patients with rheumatoid arthritis who used concentrated fish oil only or concentrated fish oil in combination with evening primrose oil in a period of 3 months. Subjects were divided into three groups. The group I consists of patients who had been taking only their regular rheumatologic therapy; group II, patients who had been taking concentrated fish oil; and group III, patients who had been taking concentrated fish oil and evening primrose oil. Peripheral blood samples were used for all the assays. We assessed the following oxidative stress markers: index of lipid peroxidation (thiobarbituric acid-reactive substances (TBARS)), hydrogen peroxide (H2O2), superoxide anion radical (O2 (-)), nitric oxide (NO), superoxide dismutase activity (SOD), catalase activity (CAT), and glutathione levels (GSH) in erythrocytes.

Results

There were no statistically significant changes for any of the oxidative stress parameters in group I. In group II, levels of TBARS, NO2 (-), and GSH were increased, while levels of H2O2 decreased. Increased values of TBARS, NO2 (-), and SOD were found in group III.

Conclusion

Our findings indicate that intakes of fish oil and evening primrose oil may be of importance in mitigation of inflammation, disease activity, and oxidative stress biomarkers, through increased activities of antioxidant enzymes.

References

Vasiljevic D1, Veselinovic M2, Jovanovic M3, Jeremic N3, Arsic A4, Vucic V4, Lucic-Tomic A2, Zivanovic S5, Djuric D6, Jakovljevic V7. Evaluation of the effects of different supplementation on oxidative status in patients with rheumatoid arthritis. Clin Rheumatol. 35(8):1909-1915. Aug  2016. doi: 10.1007/s10067-016-3168-2. Epub Jan 13 2016.

Comment

The above research indicate that fish oil and evening primrose oil may be important in mitigating inflammation, disease activity and oxidative stress biomarkers via increased antioxidant enzyme activites.

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