Research: TREMBLAY and COLLEAGUES,

Listed in Issue 273

Abstract

TREMBLAY and COLLEAGUES, 1. Institute of Nutrition and Functional Foods, Laval University, Quebec City, QC, Canada G1V 0A6; 2. Institute of Nutrition and Functional Foods, Laval University, Quebec City, QC, Canada G1V 0A6; CHUQ Research Center, Laval University, Quebec City, QC, Canada G1V 4G2 conducted a double-blind, randomized, placebo-controlled, crossover study to study the effects of n-3 PUFA supplement on the intravascular kinetics of intestinally derived apolipoprotein (apo) B-48-containing lipoproteins in 10 men with type 2 diabetes.

Background

Dietary n-3 polyunsaturated fatty acids (PUFAs) have been proposed to modulate plasma lipids, lipoprotein metabolism, and inflammatory state and to reduce triglyceride (TG) concentrations.

Methodology

The present double-blind, randomized, placebo-controlled, crossover study investigated the effects of n-3 PUFA supplementation at 3 g/d for 8 weeks on the intravascular kinetics of intestinally derived apolipoprotein (apo) B-48-containing lipoproteins in 10 men with type 2 diabetes. In vivo kinetics of the TG-rich lipoprotein (TRL) apoB-48 and VLDL apoB-100 were assessed using a primed-constant infusion of L-[5,5,5-D3] leucine for 12 hours in a fed state.

Results

Compared with the placebo, n-3 PUFA supplementation significantly reduced fasting TG concentrations by -9.7% (P = 0.05) but also significantly increased plasma levels of cholesterol (C) (+6.0%, P = 0.05), LDL-C (+12.2%, P = 0.04), and HDL-C (+8.4, P = 0.007). n-3 PUFA supplementation had no significant impact on postprandial TRL apoB-48 and VLDL apoB-100 levels or on the production or catabolic rates of these lipoproteins.

Conclusion

These data indicate that 8-week supplementation with n-3 PUFAs in men with type 2 diabetes has no beneficial effect on TRL apoB-48 and VLDL apoB-100 levels or kinetics.

References

Tremblay AJ1, Lamarche B1, Hogue JC1, Couture P2. n-3 Polyunsaturated Fatty Acid Supplementation Has No Effect on Postprandial Triglyceride-Rich Lipoprotein Kinetics in Men with Type 2 Diabetes. J Diabetes Res. 2016:2909210. 2016. doi: 10.1155/2016/2909210. Epub Feb 29 2016.

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