Research: TOLAHUNASE and COLLEAGUES,

Listed in Issue 250

Abstract

TOLAHUNASE and COLLEAGUES, 1. Lab for Molecular Reproduction and Genetics, Department of Anatomy, All India Institute of Medical Sciences (AIIMS), New Delhi, India.

2. Department of Psychiatry, All India Institute of Medical Sciences (AIIMS), New Delhi, India. Erratum in Erratum to "Impact of Yoga and Meditation on Cellular Aging in Apparently Healthy Individuals: A Prospective, Open-Label Single-Arm Exploratory Study". [Oxid Med Cell Longev. 2017] conducted a 12-week prospective, open-label, single arm exploratory  study to explore the impact of Yoga and Meditation on cellular ageing in healthy people.

Background

This study was designed to explore the impact of Yoga and Meditation based lifestyle intervention (YMLI) on cellular ageing in apparently healthy individuals.

Methodology

During this 12-week prospective, open-label, single arm exploratory study, 96 apparently healthy individuals were enrolled to receive YMLI. The primary endpoints were assessment of the change in levels of cardinal biomarkers of cellular ageing in blood from baseline to week 12, which included DNA damage marker 8-hydroxy-2'-deoxyguanosine (8-OH2dG), oxidative stress markers reactive oxygen species (ROS), and total antioxidant capacity (TAC), and telomere attrition markers telomere length and telomerase activity. The secondary endpoints were assessment of metabotrophic blood biomarkers associated with cellular ageing, which included cortisol, β-endorphin, IL-6, BDNF, and sirtuin-1.

Results

After 12 weeks of YMLI, there were significant improvements in both the cardinal biomarkers of cellular ageing and the metabotrophic biomarkers influencing cellular ageing compared to baseline values. The mean levels of 8-OH2dG, ROS, cortisol, and IL-6 were significantly lower and mean levels of TAC, telomerase activity, β-endorphin, BDNF, and sirtuin-1 were significantly increased (all values p < 0.05) post-YMLI. The mean level of telomere length was increased but the finding was not significant (p = 0.069).

Conclusion

YMLI significantly reduced the rate of cellular ageing in apparently healthy population.

References

Tolahunase M1, Sagar R2, Dada R1. Impact of Yoga and Meditation on Cellular Aging in Apparently Healthy Individuals: A Prospective, Open-Label Single-Arm Exploratory Study. Oxid Med Cell Longev. 7928981. 2017. doi: 10.1155/2017/7928981. Epub Jan 16 2017.

Comment

The above results which utilized sophisticated biochemical, DNA molecular and antioxidant measurements – cardinal biomarkers of cellular ageing – demonstrated that after only 12 weeks of the Yoga and Meditation based lifestyle intervention (YMLI), there was significantly reduced rate of cellular ageing in apparently health people. These conclusions and methodologies are overlooked at our peril.

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