Research: TANIDEH and COLLEAGUES

Listed in Issue 272

Abstract

TANIDEH and COLLEAGUES 1. a Stem cell and Transgenic Technology Research Center; 2. b Department of Pharmacology , School of Medicine; 3. c Student's Research Committee, School of Pharmacy; 4. d Pharmaceutical Sciences Research Center; 5. e Department of Pharmacology and Toxicology , School of Pharmacy; 6. f Department of Radiology , School of Medicine; 7. g Transplant Research Center; 8. h Gastrointestinal and Liver Disease Research Center , Guilan University of Medical Sciences , Rasht , Iran; 9. i Center of Comparative and Experimental Medicine , Shiraz University of Medical Science , Shiraz , Iran studied the therapeutic effects of an extract of Psidium guajava (guava) leaf on experimentally induced osteoarthritis in guinea pig

Background

The authors investigated the therapeutic effects of an extract of Psidium guajava (guava) leaf on experimentally induced osteoarthritis in guinea pig.

Methodology

The left knee of 30 male guinea pigs was anesthetized and the cranial cruciate ligament was severed. The animals were followed for 8 weeks until osteoarthritis was confirmed by radiography and histopathology. Animals were divided randomly into five groups; group 1, the ligament was severed and untreated; group 2, the ligament was severed and treated with piascledine, an extract of soybean and avocado; group 3, the ligament was severed and treated with 200 mg/kg hydroethanolic extract of guava; group 4, the ligament was severed and treated with 400 mg/kg hydroethanolic extract of guava; and group 5, control animals without surgery or extracts.

Results

Radiological and histopathological evaluations after 8 weeks showed reduced severity of osteoarthritis in the piascledine treatment group compared to group 1. The guava extract also reduce the severity of osteoarthritis compared to controls. Histopathological examination of treatment and control groups showed that treatment the guava extract improved lesions significantly.

Conclusion

Hydroethanolic extracts of guava leaf appears to prevent osteoarthritis by inhibition of free radical formation in the knee joint.

References

Tanideh N1,2, Zare Z3, Jamshidzadeh A4,5, Lotfi M6, Azarpira N7, Sepehrimanesh M8, Koohi-Hosseinabadi O9. Hydroethanolic extract of Psidium guajava leaf for induced osteoarthritis using a guinea pig model. Biotech Histochem.; 92(6):417-424. doi: 10.1080/10520295.2017.1308013. Epub Aug 22 2017. 2017

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