Research: SONKUSARE,

Listed in Issue 202


SONKUSARE, Department of Obstetrics and Gynaecology, Kasturba Medical College, Manipal University, Manipal, Karnataka 576104, India. review the clinical management of hyperemesis gravidarum - extreme morning sickness.


Hyperemesis gravidarum is a severe and disabling condition with potentially life-threatening complications.


It is likely to have a multifactorial aetiology which contributes to the difficulty in treatment.


Treatment is supportive with correction of dehydration and electrolyte disturbance, antiemetic therapy, prevention and treatment of complications like Wernicke's encephalopathy, osmotic demyelination syndrome, thromboembolism, and good psychological support.


There are abundant data on the safety of antihistamines, phenothiazines, and metoclopromide in early pregnancy and treatment should therefore not be withheld on the basis of teratogenicity concerns. Thiamine replacement is indicated in hyperemesis gravidarum to prevent development of Wernicke's encephalopathy.


Sonkusare S. The clinical management of hyperemesis gravidarum. [Review] Archives of Gynecology & Obstetrics. 283(6): 1183-92. Jun 2011.


This review is undoubtedly a good source of information for those seeking authoritative clinical information background about the pregnancy of the Duchess of Cambridge – Kate Middleton.

ICAN Skyscraper

Scientific and Medical Network 2

Cycle Around the World for Charity 2023

Climb Mount Kilimanjaro Charity 2023

Cycle from Milan to Venice for Regain 2023

top of the page