Research: SONG and COLLEAGUES,

Listed in Issue 210

Abstract

SONG and COLLEAGUES, Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA investigated the relationship between multivitamin use and risk of diabetes among older US adults.

Background

Understanding the relationship between multivitamin use and diabetes risk is important given the wide use of multivitamin supplements among US adults.

Methodology

We prospectively examined supplemental use of multivitamins and individual vitamins and minerals assessed in 1995-1996 in relation to self-reported diabetes diagnosed after 2000 among 232,007 participants in the National Institutes of Health-American Association of Retired Persons Diet and Health Study. Multivitamin use was assessed by a food-frequency questionnaire at baseline. Odds ratios (ORs) and 95% CIs were calculated by logistic regression models, adjusted for potential confounders. In total, 14,130 cases of diabetes diagnosed after 2000 were included in the analysis.

Results

Frequent use of any multivitamins was not associated with risk of diabetes after adjustment for potential confounders and uses of individual supplements. Compared with nonusers of any multivitamins, the multivariate ORs among users were 1.07 (95% CI 0.94-1.21) for taking vitamins less than once per week, 0.97 (0.88-1.06) for one to three times per week, 0.92 (0.84-1.00) for four to six times per week, and 1.02 (0.98-1.06) for seven or more times per week (P for trend = 0.64). Significantly lower risk of diabetes was associated with the use of vitamin C or calcium supplements. The multivariate ORs comparing daily users with nonusers were 0.91 (0.86-0.97) for vitamin C supplements and 0.85 (0.80-0.90) for calcium supplements. Use of vitamin E or other individual vitamin and mineral supplements were not associated with diabetes risk.

Conclusion

In this large cohort of US older adults, multivitamin use was not associated with diabetes risk. The findings of lower diabetes risk among frequent users of vitamin C or calcium supplements warrant further evaluations.

References

Song Y, Xu Q, Park Y, Hollenbeck A, Schatzkin A and Chen H. Multivitamins, individual vitamin and mineral supplements, and risk of diabetes among older U.S. adults. Source Diabetes Care. 34(1):108-14, Jan 2011. Local Messages Held at BMA Library.

Comment

The above research demonstrates that a significantly lower risk of diabetes was associated with vitamin C or calcium supplements.

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