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Research: SONG and co-workers,
Listed in Issue 108
Abstract
SONG and co-workers, Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA, have investigated the relationship between the dietary intake of magnesium, insulin concentrations in the blood, and the risk of type II diabetes.
Background
A higher intake of magnesium appears to improve glucose and insulin homeostasis; however, there are sparse prospective data on the association between magnesium intake and incidence of type 2 diabetes. This study was designed to shed some light on that association.
Methodology
In the Women's Health Study, a cohort of 39,345 women aged around 45 years with no previous history of cardiovascular disease, cancer, or type 2 diabetes completed food frequency questionnaires in 1993 and were followed for an average of 6 years. Cox proportional hazard models were used to estimate multivariate relative risks of type 2 diabetes across quintiles of magnesium intake. In a sample of 349 apparently healthy women from this study, plasma fasting insulin levels were measured in order to examine their relation to magnesium intake.
Results
During the follow-up time, 918 confirmed incident cases of type 2 diabetes were found in the study cohort. There was a significant inverse association between magnesium intake and risk of type 2 diabetes. Among women with significant overweight, the inverse trend was pronounced; multivariate-adjusted relative risks were 1.0, 0.96, 0.76, 0.84, and 0.78 for all quintiles in ascending order (p = 0.02).
Conclusion
These findings support a role of higher magnesium intake in reducing the risk of developing type 2 diabetes, especially in overweight women.
References
Song Y, Manson JE, Buring JE, Liu S. Dietary magnesium intake in relation to plasma insulin levels and risk of type 2 diabetes in women. Diabetes Care 27(1): 59-65, Jan 2004.
