Research: SHARONI and colleagues, F

Listed in Issue 25

Abstract

SHARONI and colleagues, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel write that consumption of carotenoids has frequently been inversely correlated with cancer incidence . The authors used the dimethyl-benz(a)anthracene (DMBA)-induced rat mammary tumour model to compare the effect of lycopene-enriched tomato oleoresin upon initiation and progress of these tumours with that of beta-carotene.

Background

Methodology

Rats were injected with lycopene-enriched tomato oleoresin or beta-carotene twice per week for 2 weeks prior to tumour induction by DMBA and for an additional 16 weeks following carcinogen administration.

Results

HPLC analysis of carotenoids extracted from several tissues demonstrated that both carotenoids were absorbed into blood, liver, mammary gland, and mammary tumours. The tomato oleoresin-treated rats developed significantly fewer tumours and the tumour area was smaller than that of the unsupplemented rats. The rats receiving beta-carotene showed no protection against the development of mammary cancer.

Conclusion

Lycopene significantly protected rats against the developed of mammary tumours .

References

Sharoni Y et al. Effects of lycopene-enriched tomato oleoresin on 7,12-dimethyl-benz(a)anthracene-induced rat mammary tumors. Cancer Detect Prev 21(2): 118-23. 1997.

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