Research: SÂNZIO and COLLEAGUES,

Listed in Issue 249

Abstract

SÂNZIO and COLLEAGUES, 1. Postgraduate Program in Biochemistry and Molecular Biology, Federal University of Rio Grande do Norte, Natal, Brazil. Cristianesanziogurgel@gmail.com  2. Department of Nutrition, Federal University of Rio Grande do Norte, Natal, Brazil; 3. Postgraduate Program in Biochemistry and Molecular Biology, Federal University of Rio Grande do Norte, Natal, Brazil conducted a retrospective cross-sectional study to assess the effect of multivitamin supplements with different vitamin A sources on retinol concentrations in serum and colostrum milk of postpartum women.

Background

The aim of the present study was to assess the effect of multivitamin supplements and their different vitamin A sources on retinol concentrations in serum and colostrum milk of postpartum women.

Methodology

This was a retrospective cross-sectional study composed of healthy postpartum women attending two Brazilian private maternity wards (N = 100). According to the type of multivitamin taken during pregnancy, the women were assigned to one of four groups: control group (CG; n = 25), formulation 1 (F1; n = 25), formulation 2 (F2; n = 25), and formulation 3 (F3; n = 25). Blood and colostrum samples were collected under fasting conditions and retinol was analyzed by high-performance liquid chromatography. Dietary vitamin A was assessed using a food frequency questionnaire. Retinol concentrations <20 μg/dL (<0.70 μmol/L) in serum and <60 μg/dL (2.10 μmol/L) in colostrum were considered indicative of vitamin A deficiency.

Results

Of women in the control group, 12% (n = 3) presented serum retinol levels below the cut-off value for adequacy; this was not observed in the supplemented groups. Evaluating the retinol content in breast milk, supplemented groups F1 and F3 presented 4% (n = 1) of inadequacy cases, whereas F2 presented 40% (n = 10). The concentrations found in the F2 and F3 groups were statistically different (P < 0.05).

Conclusion

The use of multivitamin supplements containing vitamin A during pregnancy prevents vitamin A deficiency regardless of the source administered. In breast milk, supplementation with β-carotene provided a lower concentration of vitamin A compared with retinol.

References

Sânzio Gurgel CS1, Alves de Araújo Pereira L2, de Assis Costa A2, Adja da Silva Souza M2, Araújo de Brito P2, Miranda de Melo LR2, Dimenstein R3. Effect of routine prenatal supplementation on vitamin concentrations in maternal serum and breast milk. Nutrition. 33:261-265. Jan 2017. doi: 10.1016/j.nut.2016.06.015. Epub 2016 Jul 26.

Munro Hall Clinic 2019

IJCA 2018 New Skyscraper

Scientific and Medical Network 2

Cycle India 2020

Walk on the Wide Side Trek Kenya 2020

Big Heart Bike Ride South Africa 2020

top of the page