Listed in Issue 258


REJI and COLLEAGUES, 1. Department of Biotechnology, Karunya University, Coimbatore-641 114, Tamil Nadu, India; 2. Department of Biotechnology, Karunya University, Karunya Nagar, Coimbatore - 641 114. Tamil Nadu, India investigated the anti-metastasis activity of free All Trans Retinoic Acid (ATRA) and liposome entrapped ATRA in lung and liver cancer using an experimental mice model.


The high mortality rate of lung cancer is highly associated with faster metastasis spread. All Trans Retinoic Acid (ATRA), being the first choice drug for leukemia therapy is now under intense study for its therapeutic efficiency in other solid cancers. This study was aimed to investigate the anti-metastasis activity of free ATRA and liposome entrapped ATRA (5:4:1) in the experimental C57BL/6 mice model developed by the injection of B16F10 cell line into the tail vein.


The ATRA drug was given via i.p for 21 days. The visual lung and liver metastatic tumour nodules were noted. Various biochemical markers of cancer metastasis in the serum as well as tissues were also analyzed after sacrifice.


RESULTS: Tumour nodules have significantly decreased in ATRA treatment groups (32.83 ± 1.83 for free ATRA, 23 ± 2.36 for DSPC Lipo-ATRA) when compared with metastasis control (63.16 ± 2.9) in the lungs. Among the treatment groups, the DSPC lipo-ATRA treated group showed a significant tumour growth inhibition (63.6%) than that of in the free ATRA treated groups (48%). Similar anti-metastatic effect was observed in liver also. Furthermore lipo-ATRA has shown a significant change in the levels of biochemical cancer markers analyzed in this study.


Our results concluded that the liposome encapsulated ATRA has an enhanced anti-metastasis potency than the free ATRA during B16F10 metastatic cell line implantation.


Reji RM1, Siddikuzzaman1, V M BG2. ATRA Entrapped in DSPC Liposome Enhances Anti-metastasis Effect on Lung and Liver During B16F10 Cell Line Metastasis in C57BL6 Mice. Anticancer Agents Med Chem.;17(6):875-884. doi: 10.2174/1871520616666160927103458. 2017.

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