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Research: RAO and colleagues, De
Listed in Issue 46
Abstract
RAO and colleagues, Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Ontario, Canada. V.rao@utoronto.ca write that tomatoes and tomato products containing lycopene the antioxidant carotenoid, have been shown in recent studies to reduce the risk of cancer . The authors conducted a study to investigate the serum and prostate tissue lycopene and other major carotenoid concentrations in cancer patients and controls.
Background
Methodology
12 prostate cancer patients and 12 age-matched controls participated in the study. Serum lipid and protein oxidation was measured, along with lycopene and carotenoid levels.
Results
Compared to the controls, significantly lower serum and tissue lycopene levels (44%, and 78%) were observed in cancer patients. Serum and tissue beta-carotene and other major carotenoids did not differ between the two groups. Serum protein thiol levels were significantly lower in cancer patients, although there was no difference in serum lipid peroxidation between the groups.
Conclusion
The results of this study demonstrates that the status of lycopene but not other carotenoids in prostate cancer patients is different from controls. The role of dietary lycopene in preventing oxidative damage of biomolecules and thereby reducing prostate cancer risk should be assessed in future studies.
References
Rao AV et al. Serum and tissue lycopene and biomarkers of oxidation in prostate cancer patients: a case-control study. Nutrition and Cancer 33(2): 159-64 1999.
