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Research: PENG and colleagues, A
Listed in Issue 39
Abstract
PENG and colleagues, Arizona Cancer Center, University of Arizona, Tucson 85724 analysed the plasma concentrations of 10 micronutrients in cervical tissue from cancerous, precancerous and noncancerous women.
Background
Methodology
Paired blood and cervical tissue (cancerous, precancerous and noncancerous) samples were taken from 87 patients, aged from 21-86 years who had a hysterectomy or biopsy due to cervical cancer, precancer (cervical intraepithelial neoplasia I, II and III) or noncancerous diseases. The samples were analysed for 10 micronutrients (lutein, zeaxanthin, beta-cryptoxanthin, lycopene, alpha-carotene, beta-carotene, cis-beta-carotene, alpha-tocopherol, gamma-tocopherol and retinol ).
Results
1) In the 3 patient groups, the mean plasma concentrations of all micronutrients except gamma-tocopherol were lowest in the cancer patients; however, the mean tissue concentrations of the two tocopherols and certain carotenoids were highest in the cancerous tissue; 2) Among the 10 micronutrients, only the concentrations of beta-carotene and cis-beta-carotene were lower in both the plasma and tissue of cancer and precancer patients than in those of noncancer controls .
Conclusion
These data suggest that: 1)not all the micronutrient concentrations in plasma reflect the micronutrient concentrations in cervical tissue. Therefore in some cases, it may be necessary to measure the tissue micronutrient concentrations in order to define the role of the micronutrients in cervical cancer; and 2) Maintaining an adequate plasma and tissue concentration of beta-carotene may be necessary for the prevention of cervical cancer and precancer .
References
Peng YM et al. Concentrations of carotenoids, tocopherols, and retinol in paired plasma and cervical tissue of patients with cervical cancer, precancer, and noncancerous diseases. Cancer Epidemiol Biomarkers Prev 7(40): 347-50 Apr 1998.
