Research: PATTANAYAK and SUNITA,

Listed in Issue 191

Abstract

PATTANAYAK and SUNITA, Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi 835215, India. shakti.pattanayak@yahoo.co.in sought to validate therapeutic claims of wound healing, anti-microbial and antioxidant activity of Dendrophthoe falcata (L.f) Ettingsh (Loranthaceae) [a plant from the family of mistletoes].

Background

Dendrophthoe falcata (L.f) Ettingsh (Loranthaceae) of the order Santalales, is used ethnomedicinally for treating ulcers, asthma, impotence, paralysis, skin diseases, and wounds. In this context, validations of the ethnotherapeutic claims of the plant in wound healing activity was studied, besides anti-microbial activity and antioxidant activity were performed to understand the mechanism of wound healing potency.

Methodology

The ethanolic extract of aerial parts of Dendrophthoe falcata ethanolic extract (DFEE) was investigated for the evaluation of its healing efficiency on excision and incision wound models in rats.

Results

The results showed that Dendrophthoe falcata extract has potent wound healing capacity as evident from the wound contraction and increased tensile strength. Hydroxyproline and hexosamine expressions were also well correlative with the healing pattern observed. Three of the fractions A-C (petroleum ether, chloroform and ethanol, respectively) obtained from the extract exhibited significant antimicrobial activity against the organisms: Staphylococcus aureus, Staphylococcus pyogenes, Staphylococcus epidermidis, Micrococcus luteus, Bacillus subtilis, Bacillus cereus, Klebsiella pneumoniae, Enterobacter aerogenes, Pseudomonas aeroginosa, Serratia marcescens, and five fungi Candida albicans, Candida tropicalis: dimorphic fungi, Aspergillus fumigatus, Aspergillus niger: systemic fungi, and some infectious bacteria Escherichia coli, and Salmonella typhi. The results also indicated that DFEE possesses potent antioxidant activity by inhibiting lipid peroxidation, reduced glutathione, superoxide dismutase levels and increased the catalase activity.

Conclusion

References

Pattanayak SP and Sunita P. Wound healing, anti-microbial and antioxidant potential of Dendrophthoe falcata (L.f) Ettingsh. Journal of Ethnopharmacology. 120 (2): 241-7. Nov 20 2008.

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