Research: PARK and COLLEAGUES,

Listed in Issue 227

Abstract

PARK and COLLEAGUES, Sang-Ho Park, Napapan Kangwan, Jong-Min Park, Eun-Hee Kim, Ki Baik Hahm, CHA Cancer Prevention Research Center, CHA Cancer Institute, CHA University, Seoul 135-081, South Korea researched to identify a non-microbial approach to treatment that provides long-term control of gastric inflammation through nutrients and other interventions.

Background

Although the International Agency for Research on Cancer declared Helicobacter pylori (H. pylori) as a definite human carcinogen in 1994, the Japanese Society for Helicobacter Research only recently (February 2013) adopted the position that H. pylori infection should be considered as an indication for either amelioration of chronic gastritis or for decreasing gastric cancer mortality.

Methodology

Japanese researchers have found that H. pylori eradication halts progressive mucosal damage and that successful eradication in patients with non-atrophic gastritis most likely prevents subsequent development of gastric cancer.

Results

However, those who have already developed atrophic gastritis / gastric atrophy retain potential risk factors for gastric cancer. Because chronic perpetuated progression of H. pylori-associated gastric inflammation is associated with increased morbidity culminating in gastric carcinogenesis, a non-microbial approach to treatment that provides long-term control of gastric inflammation through nutrients and other interventions may be an effective way to decrease this morbidity.

Conclusion

This non-microbial approach might represent a new form of prerequisite ‘rescue’ therapy that provides a quicker path to the prevention of gastric cancer as compared to simple eradication.

References

Park SH, Kangwan N, Park JM, Kim EH, Hahm KB. Non-microbial approach for Helicobacter pylori as faster track to prevent gastric cancer than simple eradication. World J Gastroenterol 21;19(47):8986-95. Dec 2013. doi: 10.3748/wjg.v19.i47.8986.

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