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Research: OKYAR and colleagues,
Listed in Issue 69
Abstract
OKYAR and colleagues, Department of Pharmacology, Faculty of Pharmacy, University of Istanbul, 34452 Universite, Istanbul, Turkey, investigated the effects of Aloe vera leaves on blood glucose levels in rat models of diabetes .
Background
Aloe species have been used traditionally in many parts of the world for their various medicinal properties. (Aloe vera (L.) Burm. fil. (= A. barbadensis Miller) (Liliaceae) is native to N. America and is also cultivated in Turkey.) Controversial reports produced over the past 15 years have claimed hypoglycaemic activity of Aloe species. Controversy [ie. variations in findings] may have resulted from the use of different parts of the plant and/or models of diabetes .
Methodology
Separate experiments were performed in three different groups of rats: non-diabetic (ND) rats; type I (IDDM) diabetic rats; and type II (NIDDM) diabetic rats.
Results
In ND rats, Aloe vera leaf pulp and gel extracts did not lower blood sugar levels . In IDDM and NIDDM rats, A. vera leaf pulp extract showed hypoglycaemic activity . In NIDDM rats, the effectiveness of A. vera leaf pulp extract was greater than that seen with glibenclamide . Conversely, A. vera leaf gel extract showed hyperglycaemic activity in NIDDM rats.
Conclusion
Aloe vera leaf pulp extract devoid of gel could be useful in the treatment of non-insulin-dependent (type II) diabetes . Okyar A et al. Effects of Aloe vera leaves on blood glucose level in type I and type II diabetic rat models. Phytotherapy Research 15 (2): 157-61. Mar 2001.
References
